To improve the efficacy of RT, advanced image-guided delivery technologies have been proposed and developed over the past decades 5, 6.
Achieving such a desired therapeutic ratio, that is, maximizing tumor control while minimizing toxicity, requires that the planned radiation dose is delivered accurately 3, 4. Successful RT is contingent on delivering intended sufficient radiation dose to tumor while sparing surrounding normal tissues 2. Radiation therapy (RT) has been shown to improve the outcomes of patients with cancer and provide palliation of related symptoms 1. These studies demonstrate the potential of iRAI to monitor and quantify the 3D radiation dose deposition during treatment, potentially improving radiotherapy treatment efficacy using real-time adaptive treatment. Finally, real-time visualization of the 3D radiation dose delivered to a patient with liver metastases was accomplished with a clinical linear accelerator. Next, semiquantitative iRAI relative dose measurements were verified in vivo in a rabbit model. The feasibility of imaging temporal 3D dose accumulation was first validated in a tissue-mimicking phantom. The method relies on a two-dimensional matrix array transducer and a matching multi-channel preamplifier board. We describe an iRAI volumetric imaging system that enables mapping of the three-dimensional (3D) radiation dose distribution in a complex clinical radiotherapy treatment. Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive feedback for cancer treatments.
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